PRMT7 Rabbit Polyclonal Antibody

CAT#: TA324052

Anti-PRMT7 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 78 kDa. Positive control: 231 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 50 ug per lane Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 40 seconds)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:1000-2000, WB: 1:200-1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 526-692 amino acids of human protein arginine methyltransferase 7
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 78 kDa
• Gene Name: protein arginine methyltransferase 7
• Database Link:
  NP_001171753
  Entrez Gene 214572 MouseEntrez Gene 361402 RatEntrez Gene 54496 Human
  UniProt ID Q9NVM4
• Background: Protein arginine methyltransferase 7?is a?protein?that in humans is encoded by the?PRMT7?gene.?Arginine?methylation?is an apparently irreversible protein modification catalyzed by arginine methyltransferases; such as PMT7; using?S-adenosylmethionine?(AdoMet) as the methyl donor. Arginine methylation is implicated in?signal transduction; RNA transport; and?RNA splicing. May be involved in etoposide-induced cytotoxicity; a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).
• Synonyms: FLJ10640; KIAA1933

Reference Data

• Protein Families: Druggable Genome