FGFR1 Rabbit Polyclonal Antibody
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Other products for "FGFR1"
Specifications
Product Data | |
Applications | ELISA, IHC |
Recommended Dilution | IHC: 50-300 Positive control: Human cervical cancer Predicted cell location: Cytoplasm |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Fusion protein corresponding to C terminal 200 amino acids of human fibroblast growth factor receptor 1 |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | fibroblast growth factor receptor 1 |
Database Link | |
Background | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family; where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region; composed of three immunoglobulin-like domains; a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors; setting in motion a cascade of downstream signals; ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome; Jackson-Weiss syndrome; Antley-Bixler syndrome; osteoglophonic dysplasia; and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however; not all variants have been fully characterized. |
Synonyms | bFGF-R; BFGFR; c-fgr; CD331; CEK; FGFBR; FGFR-1; FLG; FLJ99988; FLT2; H2; H3; H4; H5; HBGFR; KAL2; N-SAM; OGD; OTTHUMP00000190881 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
Protein Pathways | Adherens junction, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
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