Gremlin 1 (GREM1) Rabbit Polyclonal Antibody

CAT#: TA324077

Anti-GREM1 Rabbit Polyclonal Antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane: Mouse testis tissue Primary antibody: TA324077 (GREM1 Antibody) at dilution 1/700 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse testis tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 25-184 amino acids of human gremlin 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 21 kDa
• Gene Name: gremlin 1, DAN family BMP antagonist
• Database Link:
  NP_001178251
  Entrez Gene 23892 MouseEntrez Gene 50566 RatEntrez Gene 26585 Human
  UniProt ID O60565
• Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs; BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists; to which this gene belongs; is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP; this gene may play a role in regulating organogenesis; body patterning; and tissue differentiation. In mouse; this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Secreted Protein