Caspase 12 (CASP12) Rabbit Polyclonal Antibody

CAT#: TA324088

Anti-CASP12 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: NIH/3T3 cell lysate
  IHC: 30-150
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm and Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 305-320 amino acids of Human caspase 12 (gene/pseudogene)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: caspase 12 (gene/pseudogene)
• Database Link:
  NP_001177945
  Entrez Gene 12364 MouseEntrez Gene 156117 RatEntrez Gene 100506742 Human
  UniProt ID Q6UXS9
• Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents; the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However; in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
• Synonyms: CASP-12; CASP12P1