MAP3K12 Rabbit Polyclonal Antibody

CAT#: TA324095

Anti-MAP3K12 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 125-366 amino acids of human mitogen-activated protein kinase kinase kinase 12
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: mitogen-activated protein kinase kinase kinase 12
• Database Link:
  NP_006292
  Entrez Gene 25579 RatEntrez Gene 26404 MouseEntrez Gene 7786 Human
  UniProt ID Q12852
• Background: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors; such as cAMP responsive element binding protein (CREB) and MYC; and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
• Synonyms: DLK; MEKK12; MUK; ZPK; ZPKP1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: MAPK signaling pathway