IL17RC Rabbit Polyclonal Antibody

CAT#: TA324144

Anti-IL17RC Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA324144 (IL17RC Antibody) at dilution 1/20. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA324144 (IL17RC Antibody) at dilution 1/20. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human esophagus cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to N terminal 357 amino acids of Human Interleukin-17 receptor C
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 17 receptor C
• Database Link:
  NP_703193
  Entrez Gene 171095 MouseEntrez Gene 297520 RatEntrez Gene 84818 Human
  UniProt ID Q8NAC3
• Background: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA; which is predominantly expressed in hemopoietic cells; and binds with high affinity to only IL-17A; this protein is expressed in nonhemopoietic tissues; and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines; IL-17A and IL-17F; have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene; and it has been proposed that soluble; secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
• Synonyms: FLJ95963; FLJ96005; IL17-RL; IL17F receptor; IL17RL; interleukin 17 receptor-like; interleukin 17 receptor C; MGC10763

Reference Data

• Protein Families: Druggable Genome, Transmembrane