RAB11A Rabbit Polyclonal Antibody

CAT#: TA324158

Anti-RAB11A Rabbit Polyclonal Antibody

Product Images

Predicted band size: 24 kDa. Positive control: Spleen tissue, Jurkat, MCF7 and SH-SY5Y cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane 1: Spleen tissue lysate Lane 2: Jurkat cell lysate Lane 3: MCF7 cell lysate Lane 4: SH-SY5Y cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 24 kDa
• Gene Name: RAB11A, member RAS oncogene family
• Database Link:
  NP_001193765
  Entrez Gene 53869 MouseEntrez Gene 81830 RatEntrez Gene 8766 Human
  UniProt ID P62491
• Background: Rab11a, Rab11b and Rab25 are members of the Rab11 family of small Ras-like GTPases. Rab11 (isoforms Rab11a and Rab11b) functions as a key regulator in the recycling of perinuclear, plasma membrane and Golgi compartment endosomes. Despite some overlap, distinct differences exist between Rab11a and Rab11b in both their cellular distribution and functional roles. Rab11a is ubiquitously expressed while Rab11b is found mainly in the heart and brain. Like other Rab proteins, Rab11 exerts its function via interactions with Rab11 family interacting proteins (FIPs). While there are three distinct classes of FIPs, all appear to share a conserved carboxy-terminal Rab-binding domain that allows Rab-FIP protein interaction. When bound together, these proteins are thought to regulate membrane-associated protein sorting.
• Synonyms: YL8

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis