MAP4K3 Rabbit Polyclonal Antibody

CAT#: TA324260

Anti-MAP4K3 Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 50 μg Lane: Mouse heart tissue Primary antibody: TA324260 (MAP4K3 Antibody) at dilution 1/400 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA324260 (MAP4K3 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA324260 (MAP4K3 Antibody) at dilution 1/30, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Mouse heart tissue
  IHC: 25-100
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 556-867 amino acids of human mitogen-activated protein kinase kinase kinase kinase 3
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 101 kDa
• Gene Name: mitogen-activated protein kinase kinase kinase kinase 3
• Database Link:
  NP_001257354
  Entrez Gene 170920 RatEntrez Gene 225028 MouseEntrez Gene 8491 Human
  UniProt ID Q8IVH8
• Background: This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling; among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Ubiquitously expressed in all tissues examined; with high levels in heart; brain; placenta; skeletal muscle; kidney and pancreas and lower levels in lung and liver.
• Synonyms: GLK; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: MAPK signaling pathway