E2F6 Rabbit Polyclonal Antibody

CAT#: TA324290

Anti-E2F6 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of Mouse liver tissue using TA324290 (E2F6 Antibody) at dilution 1/350

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA324290 (E2F6 Antibody) (left image) at dilution 1/70, the image on the right is treated with the fusion protein. (Original magnification: x200)

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA324290 (E2F6 Antibody) (left image) at dilution 1/70, the image on the right is treated with the fusion protein. (Original magnification: x200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1:1000-2000, WB: 1:200-1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 32 kDa
• Gene Name: E2F transcription factor 6
• Database Link:
  NP_001265204
  Entrez Gene 50496 MouseEntrez Gene 313978 RatEntrez Gene 1876 Human
  UniProt ID O75461
• Background: This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain; a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP); a transactivation domain enriched in acidic amino acids; and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene; but it has not been clearly demonstrated that they encode valid isoforms.
• Synonyms: E2F-6

Reference Data

• Protein Families: Transcription Factors