DIABLO Rabbit Polyclonal Antibody

CAT#: TA324293

Anti-DIABLO Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 1000-5000
  WB positive control: Lncap, SKOV3, MCF7 and 293T cells
  IHC: 100-300
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 56-239 amino acids of human diablo, IAP-binding mitochondrial protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 27 kDa
• Gene Name: diablo IAP-binding mitochondrial protein
• Database Link:
  NP_001265231
  Entrez Gene 66593 MouseEntrez Gene 288753 RatEntrez Gene 56616 Human
  UniProt ID Q9NR28
• Background: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis; and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene; with two of them encoding different isoforms and the other two probably not encoding a protein. Ubiquitously expressed with highest expression in testis. Expression is also high in heart; liver; kidney; spleen; prostate and ovary. Low in brain; lung; thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
• Synonyms: DFNA64; SMAC

Reference Data

• Protein Families: Transmembrane