JNK1 (MAPK8) Rabbit Polyclonal Antibody

CAT#: TA324295

Anti-MAPK8 Rabbit Polyclonal Antibody


USD 345.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution WB: 500-2000
WB positive control: Jurkat, K562, Hela, A172 cell, Mouse brain tissue lysates
IHC: 50-200
Positive control: Human prostate cancer
Predicted cell location: Nucleus
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to a C terminal 300 amino acids of human mitogen-activated protein kinase 8
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 48 kDa
Gene Name mitogen-activated protein kinase 8
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals; and are involved in a wide variety of cellular processes such as proliferation; differentiation; transcription regulation and development. This kinase is activated by various cell stimuli; and targets specific transcription factors; and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis; which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation; apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.?
Synonyms 2; JNK; JNK-46; JNK1; JNK1A2; JNK21B1; PRKM8; SAPK1; SAPK1c
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase
Protein Pathways Adipocytokine signaling pathway, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, GnRH signaling pathway, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Wnt signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.