ADAM17 Rabbit Polyclonal Antibody

CAT#: TA325206

Rabbit Polyclonal ADAM 17 (Thr735) Antibody (Phospho-specific)

Product Images

Western blot analysis of ADAM 17 phosphorylation expression in K562UV treated whole cell lysates, The lane on the left is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against A synthesized peptide derived from human ADAM 17 around the phosphorylation site of Threonine 735
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 93 kDa
• Gene Name: ADAM metallopeptidase domain 17
• Database Link:
  NP_003174
  Entrez Gene 11491 MouseEntrez Gene 57027 RatEntrez Gene 6868 Human
  UniProt ID P78536
• Background: This gene encodes a disintegrin and metalloprotease (ADAM) domain 17, which is a member of the ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.
• Synonyms: ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection, Notch signaling pathway