TrkB (NTRK2) Rabbit Polyclonal Antibody

CAT#: TA325758

Rabbit Polyclonal Trk B (Tyr515) Antibody (Phospho-specific)

Product Images

Western blot analysis of Trk B phosphorylation expression in NIH-3T3 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000; IHC: 1:50-1:200
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against A synthesized peptide derived from human Trk B around the phosphorylation site of Tyrosine 515 (peptide seq 509-521aa: VIENPQY(p)FGITN)
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 145 kDa
• Gene Name: neurotrophic receptor tyrosine kinase 2
• Database Link:
  NP_001007098
  Entrez Gene 18212 MouseEntrez Gene 25054 RatEntrez Gene 4915 Human
  UniProt ID Q16620
• Background: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation.
• Synonyms: GP145-TrkB; trk-B; TRKB
• Note: The amino acid position may vary depending on the source of reference sequence: position 516 base on NP_001018074.1, position 532 base on NP_006171.2.

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: MAPK signaling pathway, Neurotrophin signaling pathway