SYK Rabbit Polyclonal Antibody

CAT#: TA325921

Rabbit Polyclonal SYK Antibody


USD 345.00

4 Weeks*

Size
    • 100 ul

Product Images

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 1:500-1:2000; IHC: 1:50-1:200
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthesized peptide derived from human SYK
Formulation Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration lot specific
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name spleen tyrosine kinase
Background The Src-related protein tyrosine kinases Lck p56 and Fyn p59 are critically involved in T cell antigen receptor (TCR)/CD3-triggered activation. T lymphocytes also express a second class of non-receptor protein tyrosine kinases which includes Syk p70 and ZAP p72. These kinases resemble the Src family protein tyrosine kinases in that they have a C-terminal catalytic domain, but differ in that they are characterized by two SH2 domains but no SH3 domains. Evidence for the involvement of the Syk/ZAP family proteins in T cell activation was suggested by the finding that Syk p72 kinase fused to the transmembrane and extracellular domains of CD7 and DC16, respectively, can induce complete T cell activation. In contrast, the ZAP p70 kinase was insufficient unless it was coaggregated with a Fyn p59-containing chimera,suggesting that regulation of ZAP p70 activity may require a functional interaction with Src family kinases.
Synonyms p72-Syk
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.