HIF 2 alpha (EPAS1) Mouse Monoclonal Antibody [Clone ID: EP190B]

CAT#: TA326351

Mouse monoclonal HIF2 alpha Antibody

Product Images

Western blot analysis of HIF2 Alpha in CoCl treated HeLa lysates, using a 1:1000 dilution of the antibody

• 

  IHC analysis of HIF2Alpha using mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute.

Specifications

Product Data

• Clone Name: EP190B
• Applications: IHC, WB
• Recommended Dilution: WB: 1:100-1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: GST-human EPAS-1 (HIF2alpha) amino acids 535-631 fusion protein
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: endothelial PAS domain protein 1
• Database Link:
  NP_001421
  Entrez Gene 2034 Human
• Background: Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia . HIF2-Alpha is involved in catecholamine homeostasis, vascular remodeling, physiological angiogenesis and adipogenesis. It is overexpressed in many cancerous tissues, but its exact role in tumour progression remains to be clarified . Studies suggest that in the case of non-small cell lung cancer, HIF2-Alpha actually is a promoter of tumor growth and progression in a solid tumor . Other data suggests that HIF2-Alpha is an important regulator of innate immunity, and therefore may be useful in the therapeutic target for treating inflammatory disorders and cancer .
• Synonyms: bHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2
• Note: Human

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Renal cell carcinoma