Grp75 (HSPA9) Mouse Monoclonal Antibody [Clone ID: S52A-42]

CAT#: TA326364

Mouse monoclonal Grp75 Antibody

Product Images

Western blot analysis of Grp75 in HeLa cell lysates using a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: S52A-42
• Applications: WB
• Recommended Dilution: WB (colorimetric): 1:1000
• Reactivities: Human, Mouse, Rat. Other species not tested yet
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Peptide immunogen to SALM2
• Formulation: PBS pH7.2, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: heat shock protein family A (Hsp70) member 9
• Database Link:
  NP_004125
  Entrez Gene 15526 MouseEntrez Gene 291671 RatEntrez Gene 3313 Human
  UniProt ID P38646
• Background: Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible . Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle . Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53 . Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation . Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts . And finally, like its E.coli homolog DnaK , GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone .
• Synonyms: CSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74
• Note: Detects ~75kDa.

Reference Data

• Protein Families: Stem cell - Pluripotency
• Protein Pathways: RNA degradation