Grp75 (HSPA9) Mouse Monoclonal Antibody [Clone ID: S52A-42]
Other products for "HSPA9"
Specifications
Product Data | |
Clone Name | S52A-42 |
Applications | WB |
Recommended Dilution | WB (colorimetric): 1:1000 |
Reactivities | Human, Mouse, Rat. Other species not tested yet |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Peptide immunogen to SALM2 |
Formulation | PBS pH7.2, 50% glycerol |
Concentration | lot specific |
Purification | Protein G Purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | heat shock protein family A (Hsp70) member 9 |
Database Link | |
Background | Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible . Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle . Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53 . Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation . Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts . And finally, like its E.coli homolog DnaK , GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone . |
Synonyms | CSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74 |
Note | Detects ~75kDa. |
Reference Data | |
Protein Families | Stem cell - Pluripotency |
Protein Pathways | RNA degradation |
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