Grp75 (HSPA9) Mouse Monoclonal Antibody [Clone ID: S52A-42]

CAT#: TA326364

Mouse monoclonal Grp75 Antibody


USD 405.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name S52A-42
Applications WB
Recommended Dilution WB (colorimetric): 1:1000
Reactivities Human, Mouse, Rat. Other species not tested yet
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Peptide immunogen to SALM2
Formulation PBS pH7.2, 50% glycerol
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name heat shock protein family A (Hsp70) member 9
Background Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible . Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle . Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53 . Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation . Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts . And finally, like its E.coli homolog DnaK , GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone .
Synonyms CSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74
Note Detects ~75kDa.
Reference Data
Protein Families Stem cell - Pluripotency
Protein Pathways RNA degradation

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.