p23 (PTGES3) Mouse Monoclonal Antibody [Clone ID: JJ6]

CAT#: TA326391

Mouse monoclonal p23 Antibody

Product Images

Western blot analysis of p23 in a human cell line mix at a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: JJ6
• Applications: WB
• Recommended Dilution: WB: 1:2000
• Reactivities: Human, Mouse, Rabbit, Chicken, Guinea pig, S. cerevisiae (lower)
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human full length p23 protein
• Formulation: PBS, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: prostaglandin E synthase 3
• Database Link:
  NP_006592
  Entrez Gene 56351 MouseEntrez Gene 10728 Human
  UniProt ID Q15185
• Background: p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system . Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure . p23 does not have any structural homology with any other known proteins . p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with hsp70, p54 and p50 . p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain . Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase , the heme regulated kinase HRI , hsf1 transcription factor , aryl hydrocarbon receptor , telomerase , and Hepadnavirus reverse transcriptase . In spite of several years of study, the exact functional significance of p23 is still not clear . p23 is thought to be involved in the adenosine triphosphatemediated hsp90 binding of client proteins . Since many hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis . Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
• Synonyms: cPGES; P23; TEBP
• Note: Detects ~23kDa.

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor