WAVE 1 (WASF1) Mouse Monoclonal Antibody [Clone ID: S91-36]

CAT#: TA326418

Mouse monoclonal WAVE1/SCAR Antibody

Specifications

Product Data

• Clone Name: S91-36
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synthetic peptide amino acids 477-498 of human Wave1/Wasp family1
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: WAS protein family member 1
• Database Link:
  NP_003922
  Entrez Gene 83767 MouseEntrez Gene 294568 RatEntrez Gene 8936 Human
  UniProt ID Q92558
• Background: The Wiskott-Aldrich syndrome protein (WASP) family plays essential roles in the regulation of actin polymerization. There are five WASP family members: Wasp, N-WASP, Wave1 (WASP family verprolin-homologous protein 1), WAVE2 and WAVE3. The Wasp family proteins share a conserved C-terminal region called the verprolin homology, cofilin homology and acidic domain . The Wave/Scar family of prtoteins mediates signals to actin assembly by direct activation of the Arp2/3 complex. These proteins have been characterized as major regulators of lamellipodia formation downstream of Rac activation, and as members of large protein complexes. IT has been found that all three Scar/Wave isoforms behave similarily and are likely to participate in the same kinds of protein complexes .
• Synonyms: SCAR1; WAVE; WAVE1
• Note: Detects ~75kDa.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adherens junction, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton