Superoxide Dismutase 3 (SOD3) Mouse Monoclonal Antibody [Clone ID: 4GG11G6]

CAT#: TA326420

Mouse monoclonal SOD (EC) Antibody


USD 405.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 4GG11G6
Applications IF
Recommended Dilution WB: 1:1000, IHC: 1:100, ICC: 1:100
Reactivities Human, Rat, Mouse. Other species not yet tested
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Human EC SOD purified from aortas
Formulation PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name superoxide dismutase 3, extracellular
Background Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body . It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase . In general, SODs play a major role in antioxidant defense mechanisms . There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge . The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space . SOD3 can also be distinguished by its heparin-binding capacity .
Synonyms EC-SOD
Note Detects EC SOD at ~35kDa.
Reference Data
Protein Families Druggable Genome, Secreted Protein

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