Superoxide Dismutase 3 (SOD3) Mouse Monoclonal Antibody [Clone ID: 4GG11G6]

CAT#: TA326420

Mouse monoclonal SOD (EC) Antibody

Product Images

ICC staining of human cartilage samples using the antibody

Specifications

Product Data

• Clone Name: 4GG11G6
• Applications: IF
• Recommended Dilution: WB: 1:1000, IHC: 1:100, ICC: 1:100
• Reactivities: Human, Rat, Mouse. Other species not yet tested
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Human EC SOD purified from aortas
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: superoxide dismutase 3, extracellular
• Database Link:
  NP_003093
  Entrez Gene 20657 MouseEntrez Gene 25352 RatEntrez Gene 6649 Human
  UniProt ID P08294
• Background: Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body . It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase . In general, SODs play a major role in antioxidant defense mechanisms . There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge . The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space . SOD3 can also be distinguished by its heparin-binding capacity .
• Synonyms: EC-SOD
• Note: Detects EC SOD at ~35kDa.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein