GSK3 beta (GSK3B) Rabbit Polyclonal Antibody [Clone ID: N/A]

CAT#: TA326426

Rabbit polyclonal GSK-3Beta Antibody

Product Images

Western blot analysis of GSK-3Beta in a cell line mix, using a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: N/A
• Applications: WB
• Recommended Dilution: WB: 1:2000
• Reactivities: Bovine, Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to the sequence near the C-terminus of human GSK-3Beta.
• Formulation: PBS pH7.4
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: glycogen synthase kinase 3 beta
• Database Link:
  NP_002084
  Entrez Gene 56637 MouseEntrez Gene 84027 RatEntrez Gene 2932 Human
  UniProt ID P49841
• Background: Glycogen synthase kinase 3, is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. It has also been shown to regulate immune and migratory processes, and is tied to pathways of cell proliferation and apoptosis .In mammals, it is encoded by two genes- GSK-3Alpha and GSK-3Beta. They are structurally similar, but functionally non-identical. GSK-3Alpha is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3Beta negatively regulates cardiac hypertrophy and cardiac development through its effect on WNT signaling . GSK-3 alpha and GSK-3 beta share 85% amino acid identity. GSK-3 has been implicated in a number of diseases including Type II diabetes, Alzheimers, cancer and bipolar .
• Synonyms: glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; GSK3beta isoform
• Note: Detects ~47kDa.

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Alzheimer's disease, Axon guidance, Basal cell carcinoma, B cell receptor signaling pathway, Cell cycle, Chemokine signaling pathway, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Hedgehog signaling pathway, Insulin signaling pathway, Melanogenesis, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, T cell receptor signaling pathway, Wnt signaling pathway