PSD95 (DLG4) Mouse Monoclonal Antibody [Clone ID: S28-43]

CAT#: TA326433

Mouse monoclonal PSD95 Antibody


USD 410.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name S28-43
Applications IF, IHC
Recommended Dilution WB: 1:1000
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Fusion protein amino acids 77-200 of human PSD95/SAP90
Formulation PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name discs large MAGUK scaffold protein 4
Background Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex . These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds toneuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) . The protein is implicated in experience dependent plasticity and plays an indispensable role in learning . Mutations in PSD95 are associated with autism .
Synonyms PSD95; SAP-90; SAP90
Note Detects ~95-110kDa.
Reference Data
Protein Families Druggable Genome
Protein Pathways Huntington's disease

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