Calcineurin A (PPP3CA) Rabbit Polyclonal Antibody

CAT#: TA326450

Rabbit Polyclonal Anti-Calcineurin A Antibody

Specifications

Product Data

• Recommended Dilution: WB: 1:1000
• Reactivities: Canine, Human, Mouse, Rabbit, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Human Calcineurin A peptide (AA 364-283)
• Formulation: PBS pH 7.4; 50% glycerol, 0.09% azide
• Concentration: lot specific
• Purification: Peptide Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein phosphatase 3 catalytic subunit alpha
• Database Link:
  NP_000935
  Entrez Gene 19055 MouseEntrez Gene 24674 RatEntrez Gene 5530 Human
  UniProt ID Q08209
• Background: Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59KDa) the active site and a Ca2+ binding unit, Calcineurin B (19-20KDa) the regulatory subunit. Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs. Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506 .
• Synonyms: CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B
• Note: Identifies a band at ~61kD on a WB

Reference Data

• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Axon guidance, B cell receptor signaling pathway, Calcium signaling pathway, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway