Stx1a Mouse Monoclonal Antibody [Clone ID: SP-6]

CAT#: TA326453

Mouse Monoclonal Anti-Syntaxin Antibody

Product Images

Western blot analysis of Syntaxin in a rat tissue mix using a 1:1000 dilution of the antibody

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  Syntaxin visulaized using the antibody

Specifications

Product Data

• Clone Name: SP-6
• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Raised against synaptic vasicle-containing fractions of immunoprecipitated human brain homogenate
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: syntaxin 1A (brain)
• Database Link:
  NP_058081
  Entrez Gene 116470 RatEntrez Gene 20907 Mouse
• Background: Syntaxins are a family of membrane integrated Q-SNARE proteins participating in exocytosis . They possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. This SNARE domain binds to synaptobrevin and SNAP-25 to form the SNARE complex . Support of syntaxins involvement in vesicular transport and neurotransmission includes the requirement of its yeast homologs, SSO 1 and 2, in targeting and fusion of Golgi-derived vesicles with the plasma membrane . Syntaxin also provides the target pf clostridial neurotoxin C1, which blocks neurotransmitter release . The formation of 20S complex involves the interaction of VAMP with syntaxin through an ATP-dependent reaction modulated by synaptotagmin, SNAP-25, a-SNAP and NSF .
• Synonyms: HPC-1; p35-1; STX1
• Note: Detects ~38kDa