Amyloid Precursor Protein (APP) Rabbit Polyclonal Antibody

CAT#: TA326459

Rabbit Polyclonal Anti-Amyloid Oligomers (A11) Antibody

Product Images

Dot blot analysis of Aβ42 and polyQ36 prefibrillar oligomers and fibrils. Aβ42 and polyQ fibrils only stain with OC serum, while Aβ42 and polyQ prefibrillar oligomers only react with A11 (Catalog # TA326459).

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  Western blot analysis of A?42 fibrils and prefibrillar oligomers. A?42 fibrils (F) and prefibrillar oligomers (O) were run on SDS polyacrylamide gels, transferred to nitrocellulose and probed with OC and A11 antibodies.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: IHC: 1:1000-1:10000, IP: 1:1000
• Reactivities: Human, Mouse, Rat, Eukaryotes
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic molecular mimic of soluble oligomers.
• Formulation: PBS, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein A Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: amyloid beta precursor protein
• Database Link:
  NP_000475
  Entrez Gene 11820 MouseEntrez Gene 54226 RatEntrez Gene 351 Human
  UniProt ID P05067
• Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils.Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres . These include the amyloid- peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimers symptomology, the deposition of -synuclein in the Lewy bodies of Parkinsons disease, and accumulation of polyglutamine-containing aggregates in Huntingtons disease .
• Synonyms: AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
• Note: Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease