GRP78 (HSPA5) Mouse Monoclonal Antibody [Clone ID: 6H4.2G7]

CAT#: TA326480

Mouse Monoclonal Anti-Grp78 Antibody


USD 375.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 6H4.2G7
Applications IHC, WB
Recommended Dilution WB: 1:2000
Reactivities Human. Other species not yet tested
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen His-tagged human GRP78
Formulation PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name heat shock protein family A (Hsp70) member 5
Background GRP78 is a ubiquitously expressed, 78-kDa glucose- regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5 nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed .GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis . Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival .In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress , and its protein levels are reduced in the brains of Alzheimers patients . Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs .
Synonyms BIP; GRP78; HEL-S-89n; MIF2
Note Detects a protein with a mass of ~78kDa corresponding to GRP78
Reference Data
Protein Families Druggable Genome
Protein Pathways Antigen processing and presentation, Prion diseases

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.