KCNMB2 Mouse Monoclonal Antibody [Clone ID: S53-32]

CAT#: TA326488

Mouse Monoclonal Anti-BK Beta2 Antibody

Product Images

Western blot analysis of BK Beta2 in a human cell line mix using a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: S53-32
• Applications: WB
• Recommended Dilution: WB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 1-41 (N-terminus) and 218-235 (C-terminus) of mouse BKBeta2 (
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium calcium-activated channel subfamily M regulatory beta subunit 2
• Database Link:
  NP_852006
  Entrez Gene 72413 MouseEntrez Gene 294961 RatEntrez Gene 10242 Human
  UniProt ID Q9Y691
• Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release . A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia . This has major implications on other physiological processes in tissues other than the brain.
• Synonyms: MGC22431
• Note: Detects endogenous and exogenous hsp22 in monomeric, dimeric and tetrameric forms in WB. Does not cross react with alpha crystallin.

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction