Noelin (OLFM1) Mouse Monoclonal Antibody [Clone ID: S96-7]

CAT#: TA326496

Mouse Monoclonal Anti-Pancortin Antibody

Product Images

IHC analysis of Pancortin in frozen sections of mouse brain extract using the antibody

Specifications

Product Data

• Clone Name: S96-7
• Applications: IHC
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synthetic peptide of amino acids 28-48 of human pancortin-1 (SLVGLNTTRLSAASGGTLDRS)
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: olfactomedin 1
• Database Link:
  NP_055094
  Entrez Gene 56177 MouseEntrez Gene 93667 RatEntrez Gene 10439 Human
  UniProt ID Q99784
• Background: Pancortin, a member of a diverse family of secreted glycoproteins, is implicated in the development of the nervous system, and the glaucoma-associated protein myocilin . Studies suggest that Pancortin-2 interact with WAVE1 in a novel cell death cascade in adult, but not embryonic, cerebral cortical neurons. Specifically pancortin-2 is a mediator of ischemia-induced apoptosis of neurons in the adult cerebral cortex, and functions in a novel mitrochondrial/actin associated protein complex that sequesters Bcl-xL . It is also involved in the generation of neural crest cells, and in neurogenesis .
• Synonyms: AMY; NOE1; NOELIN1; OlfA
• Note: Detects ~70kDa (Pancortin-1, Pancortin-3) and ~20kDa (Pancortin-2 and Pancortin-4).

Reference Data

• Protein Families: Druggable Genome