SCN1A Mouse Monoclonal Antibody [Clone ID: S74-71]

CAT#: TA326498

Mouse Monoclonal Anti-Nav1.1 Antibody

Product Images

IHC analysis of Nav1.1 in frozen sections of mouse brain extract using the antibody

Specifications

Product Data

• Clone Name: S74-71
• Applications: IHC
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 1929-2009 (cytoplamsic C-terminus) of rat Nav1.1
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sodium voltage-gated channel alpha subunit 1
• Database Link:
  NP_001159435
  Entrez Gene 20265 MouseEntrez Gene 81574 RatEntrez Gene 6323 Human
  UniProt ID P35498
• Background: Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing .
• Synonyms: EIEE6; FEB3; FEB3A; FHM3; GEFSP2; HBSCI; NAC1; Nav1.1; SCN1; SMEI
• Note: Detects ~220kDa. No cross reactivity against Nav1.2, Nav1.3 and Nav1.6

Reference Data

• Protein Families: Druggable Genome, Transmembrane