Abcc8 Mouse Monoclonal Antibody [Clone ID: S289-16]

CAT#: TA326508

Mouse Monoclonal Anti-SUR1 Antibody

Specifications

Product Data

• Clone Name: S289-16
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivities: Hamster, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ATP binding cassette subfamily C member 8
• Database Link:
  NP_037171
  Entrez Gene 20927 MouseEntrez Gene 25559 Rat
  UniProt ID Q09429
• Background: Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea classof antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. Morespecifically, SUR proteins are subunits of the inward rectifier potassium ion channels Kir6.x (6.1 and 6.2) .The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as theKATP channel.The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADPand in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell .
• Synonyms: ABC36; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; TNDM2
• Note: Detects ~160kDa. Does not cross-react with SUR2B