Aqp4 Rabbit Polyclonal Antibody

CAT#: TA326513

Rabbit Polyclonal Anti-Aquaporin 4 Antibody

Product Images

Western blot analysis of Aquaporin 4 in rat kidney lysates using a 1:2000 dilution of the antibody

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  IF analysis of Aquaporin 4 in rat kidney tissue using a 1:200 dilution of the antibody

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB 1:1000-4000, IF: 1:400
• Reactivities: Human, Mouse, Rat. Not yet tested on other species
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal peptide
• Formulation: PBS pH7.4, 50% glycerol and 0.09% sodium azide
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: aquaporin 4
• Database Link:
  NP_036957
  Entrez Gene 361 HumanEntrez Gene 11829 MouseEntrez Gene 25293 Rat
  UniProt ID P47863
• Background: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins .Aquaporin 4 is constitutively expressed in the basolateral cell membrane of princinpal collecting duct cells in the kidney and provide a pathway for water to exit these cells . It is also expressed in astrocytes and is upregulated by direct insult to the CNS . Aquaporin 4 has been propsed as the primary autoimmune target in neuromyelitis optica .
• Synonyms: AQP-4; aquaporin-4; HMIWC2; MGC22454; MIWC; WCH4
• Note: Detects ~35kDa. May detect larger glycosylated bands ~50kDa.