Cask Mouse Monoclonal Antibody [Clone ID: S56A-50]

CAT#: TA326522

Mouse Monoclonal Anti-CASK Antibody

Product Images

Western blot analysis on rat brain membrane tissues using a 1:1000 dilution of the antibody

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  IHC analysis of CASK in frozen sections of mouse brain extract using the antibody

Specifications

Product Data

• Clone Name: S56A-50
• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human, Mouse, Rat, Xenopus, Zebrafish
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 318-415 of rat CASK/Lin2
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
• Database Link:
  NP_071520
  Entrez Gene 8573 HumanEntrez Gene 12361 MouseEntrez Gene 29647 Rat
  UniProt ID Q62915
• Background: CASK (calmodulin sensitive kinase) is a ~112kDa member of the membrane associated quanylate kinase (MAGUK) protein family. It is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, a SH3 domain, aguanylate kinase homology domain (GUK) and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to Neurexin to stabilize pre- and post-synaptic structrures . While most of CASK proteins are cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional co-activator . Manifesting the importance of CASK, transgenic mice with insertional mutations die within 24 hours of births . CASK is also localized in the nuclei of basal keratinocytes in newborn rodent skin and developing hair follicles. It may play a role in wound healing .
• Synonyms: CAGH39; CMG; FGS4; FLJ22219; FLJ31914; hCASK; LIN2; MICPCH; TNRC8
• Note: Detects ~100kDa.