Clcn3 Mouse Monoclonal Antibody [Clone ID: S258-5]

CAT#: TA326523

Mouse Monoclonal Anti-Clcn3 Antibody

Specifications

Product Data

• Clone Name: S258-5
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: chloride voltage-gated channel 3
• Database Link:
  NP_445815
  Entrez Gene 1182 HumanEntrez Gene 12725 MouseEntrez Gene 84360 Rat
  UniProt ID P51792
• Background: Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributesto the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking andexocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory.
• Synonyms: ClC-3; CLC3
• Note: Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results)