Dlg3 Mouse Monoclonal Antibody [Clone ID: S19-2]

CAT#: TA326526

Mouse Monoclonal Anti-SAP102 Antibody

Product Images

Western blot analysis of SAP102 in rat brain extract using a dilution of 1:1000 of the antibody

Specifications

Product Data

• Clone Name: S19-2
• Applications: WB
• Recommended Dilution: WB: 1:1000 (ECL)
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 1-120 of rat SAP102
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: discs large homolog 3
• Database Link:
  NP_113827
  Entrez Gene 1741 HumanEntrez Gene 53310 MouseEntrez Gene 58948 Rat
  UniProt ID Q62936
• Background: Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal . SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain . All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway . SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains . In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
• Synonyms: KIAA1232; MRX; MRX90; NE-Dlg; NEDLG; neuroendocrine-DLG; SAP-102; SAP102; XLMR
• Note: Detects ~105kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.