Itpr1 Mouse Monoclonal Antibody [Clone ID: S24-18]

CAT#: TA326547

Mouse Monoclonal Anti-IP3 Receptor Antibody

Product Images

Western blot analysis of IP3 Receptor on rat brain membrane tissues using a 1:1000 dilution of the antibody

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  IHC analysis of IP3 Receptor using the antibody

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  IHC analysis of IP3 Receptor using the antibody

Specifications

Product Data

• Clone Name: S24-18
• Applications: IHC, WB
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: inositol 1,4,5-trisphosphate receptor, type 1
• Database Link:
  NP_001007236
  Entrez Gene 3708 HumanEntrez Gene 16438 MouseEntrez Gene 25262 Rat
• Background: Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family, and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3 receptor 1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation . Four individual receptor subunits, resulting in homo- or heterooligomerization of the receptor isoform, form a functional channel . Phosphorylation of IP3R1 at Ser1756 by cyclic- AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release . IP3R1 mediated calcium release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells .
• Synonyms: DKFZp313E1334; DKFZp313N1434; Insp3r1; IP3R; IP3R1; SCA15; SCA16
• Note: Detects ~300kDa. Does not recognize type 2 or type 3 IP3R's.