Itpr1 Mouse Monoclonal Antibody [Clone ID: S24-18]
Other products for "Itpr1"
Specifications
Product Data | |
Clone Name | S24-18 |
Applications | IHC, WB |
Recommended Dilution | WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1 |
Formulation | PBS pH7.4, 50% glycerol |
Concentration | lot specific |
Purification | Protein G Purified |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | inositol 1,4,5-trisphosphate receptor, type 1 |
Database Link | |
Background | Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family, and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3 receptor 1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation . Four individual receptor subunits, resulting in homo- or heterooligomerization of the receptor isoform, form a functional channel . Phosphorylation of IP3R1 at Ser1756 by cyclic- AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release . IP3R1 mediated calcium release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells . |
Synonyms | DKFZp313E1334; DKFZp313N1434; Insp3r1; IP3R; IP3R1; SCA15; SCA16 |
Note | Detects ~300kDa. Does not recognize type 2 or type 3 IP3R's. |
Reference Data |
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