Nalcn Mouse Monoclonal Antibody [Clone ID: S187-7]

CAT#: TA326572

Mouse Monoclonal Anti-NALCN Antibody

Specifications

Product Data

• Clone Name: S187-7
• Recommended Dilution: WB: 1ug/ml
• Reactivities: Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids1659-1738 (cytoplasmic Cterminus) of rat NALCN
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sodium leak channel, non-selective
• Database Link:
  NP_705894
  Entrez Gene 338370 MouseEntrez Gene 266760 Rat
  UniProt ID Q6Q760
• Background: NALCN (sodium leak channel non-selective protein), also known as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system.Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable tosodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductancein neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.
• Synonyms: bA430M15.1; CanIon; FLJ23913; FLJ44659; FLJ44764; MGC74524; VGCNL1
• Note: Detects ~200kDa.