Slc12a5 Mouse Monoclonal Antibody [Clone ID: S1-12]

CAT#: TA326588

Mouse Monoclonal Anti-KCC2 Antibody

Product Images

Western blot analysis of KCC2 on rat membrane tissues using a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: S1-12
• Applications: WB
• Recommended Dilution: IHC: 1:300
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 932-1043 corresponding to rat KCC2
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: solute carrier family 12 member 5
• Database Link:
  NP_599190
  Entrez Gene 57138 MouseEntrez Gene 57468 HumanEntrez Gene 171373 Rat
  UniProt ID Q63633
• Background: KCC2 is a member of the cation-chloride cotransporter gene family . It acts as a K-Cl cotransporter. KCCsnormally lower intracellular chloride concentrations below the electrochemical equilibrium potential anddepending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a netefflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizingpostsynaptic inhibition in the brain . KCC2 is expressed at high levels in neurons throughout thenervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinalcord . Studies in mice have shown that KCC2 reduces GABAs inhibitory signaling, resulting in motor defects,epilepsy, and anxiety-like behavior.
• Synonyms: hKCC2; KCC2; KIAA1176
• Note: Detects ~140kDa.