Sod2 Rabbit Polyclonal Antibody

CAT#: TA326596

Rabbit Polyclonal Anti-SOD (Mn) Antibody


USD 430.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommended Dilution 0.5ug/ml was sufficient for detection of Mn SOD in 20ug of rat brain tissue extract
Reactivities Human, Rat, Mouse, Bovine, Canine, Chicken, Dosophila, Guinea Pig, Pig, Hamster, Monkey, Rabbit, Sheep, Xenopus
Host Rabbit
Clonality Polyclonal
Immunogen Rat Mn SOD
Formulation PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration lot specific
Purification Affinity (antigen) Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name superoxide dismutase 2, mitochondrial
Background Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body . It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase . In general, SODs play a major role in antioxidant defense mechanisms . There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge . The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space . SOD3 can also be distinguished by its heparin-binding capacity .
Synonyms IPO-B; Mn-SOD; MNSOD; MVCD6
Note Detects a ~25kDa protein corresponding to the molecular mass of Mn superoxide dismutase (SOD) on SDS PAGE immunoblots.
Reference Data

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