TFEB Rabbit Polyclonal Antibody

CAT#: TA326618

Rabbit Polyclonal TFEB Antibody

Product Images

Immunohistochemistry of TFEB in human lung tissue with TFEB antibody at 2.5 ug/mL.

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  Immunofluorescence of TFEB in human lung tissue with TFEB antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC
• Recommended Dilution: IHC: 2.5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal TFEB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TFEB.
• Formulation: TFEB antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TFEB antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transcription factor EB
• Database Link:
  NP_009093
  Entrez Gene 7942 Human
  UniProt ID P19484
• Background: The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2). Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4). Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5).
• Synonyms: ALPHATFEB; BHLHE35; TCFEB

Reference Data

• Protein Families: Druggable Genome, Transcription Factors