p95 NBS1 (NBN) Rabbit Polyclonal Antibody

CAT#: TA326621

Rabbit Polyclonal NIBRIN Antibody

Product Images

Western blot analysis of NIBRIN in rat lung tissue lysate with NIBRIN antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of NIBRIN (NT) in human lung tissue with NIBRIN (NT) antibody at 2.5 ug/mL.

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  Immunofluorescence of NIBRIN in human lung tissue with NIBRIN antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NIBRIN antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NIBRIN.
• Formulation: NIBRIN Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: NIBRIN Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: nibrin
• Database Link:
  NP_002476
  Entrez Gene 27354 MouseEntrez Gene 85482 RatEntrez Gene 4683 Human
  UniProt ID O60934
• Background: NIBRIN Antibody: NIBRIN (NBN) is a member of the double-strand break repair complex MRE11/RAD50/NBN (MRN) which is involved in DNA double-strand break repair, DNA damage-induced checkpoint activation and plays a critical role in the maintenance of chromosome integrity. NIBRIN contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. Mutations in this gene are associated with Nijmegen breakage syndrome and maybe the cause of cancer predisposition and aplastic anemia.
• Synonyms: AT-V1; AT-V2; ATV; NBS; NBS1; P95

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Homologous recombination