SDHD Rabbit Polyclonal Antibody

CAT#: TA326622

Rabbit Polyclonal SDHD Antibody

Product Images

Western blot analysis of SDHD in EL4 cell lysate with SDHD antibody at (A) 1 and (B) 2 ug/mL.

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  Immunocytochemistry of SDHD in EL4 cells with SDHD antibody at 2.5 ug/mL.

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  Immunofluorescence of SDHD in EL4 cells with SDHD antibody at 20 ug/mL.

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  Immunocytochemistry of SDHD in EL4 cells with SDHD antibody at 2.5 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SDHD antibody was raised against a 15 amino acid synthetic peptide near the center of human SDHD.
• Formulation: SDHD Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SDHD Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: succinate dehydrogenase complex subunit D
• Database Link:
  NP_002993
  Entrez Gene 66925 MouseEntrez Gene 363061 RatEntrez Gene 6392 Human
  UniProt ID O14521
• Background: SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
• Synonyms: CBT1; CII-4; CWS3; cybS; PGL; PGL1; QPs3; SDH4

Reference Data

• Protein Pathways: Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease