Apolipoprotein E (APOE) Rabbit Polyclonal Antibody

CAT#: TA326636

Rabbit Polyclonal APO-E Antibody

Product Images

Western blot analysis of APO-E in human brain tissue lysate with APO-E antibody at (A) 0.5 and (B) 1 ug/mL.

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  Immunohistochemistry of APO-E inhuman liver tissue with APO-E antibody at 2.5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: APO-E antibody was raised against a 19 amino acid peptide near the carboxy terminus of human APO-E.
• Formulation: APO-E Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: APO-E Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 35 kDa; Observed: 34 kDa
• Gene Name: apolipoprotein E
• Database Link:
  NP_000032
  Entrez Gene 11816 MouseEntrez Gene 25728 RatEntrez Gene 348 Human
  UniProt ID P02649
• Background: APO-E Antibody: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E (APO-E), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in APO-E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
• Synonyms: AD2; APO-E; LDLCQ5; LPG

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency
• Protein Pathways: Alzheimer's disease