DOPA Decarboxylase (DDC) Rabbit Polyclonal Antibody

CAT#: TA326643

Rabbit Polyclonal DDC Antibody

Product Images

Western blot analysis of DDC in human lung tissue lysate with DDC antibody at 1 ug/ml.

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  Immunohistochemistry of DDC in human lung tissue with DDC antibody at 2.5 ug/mL.

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  Immunofluorescence of DDC in human lung tissue with DDC antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DDC antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DDC
• Formulation: DDC Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DDC Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 53 kDa; Observed: 50 kDa
• Gene Name: dopa decarboxylase
• Database Link:
  NP_000781
  Entrez Gene 13195 MouseEntrez Gene 24311 RatEntrez Gene 1644 Human
  UniProt ID P20711
• Background: DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1). It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2). It can form a homodimer and is expressed in the central nervous system (2). DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4). Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4).
• Synonyms: AADC

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Histidine metabolism, Metabolic pathways, Phenylalanine metabolism, Tryptophan metabolism, Tyrosine metabolism