Vinculin (VCL) Rabbit Polyclonal Antibody

CAT#: TA326660

Rabbit Polyclonal Vinculin Antibody


USD 430.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Vinculin antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Vinculin.
Formulation Vinculin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Vinculin Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 117 kDa; Observed: 120 kDa
Gene Name vinculin
Background Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).
Synonyms CMD1W; CMH15; HEL114; MV; MVCL
Reference Data
Protein Families Druggable Genome
Protein Pathways Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.