IL37 Rabbit Polyclonal Antibody

CAT#: TA326662

Rabbit Polyclonal IL-37 Antibody

Product Images

Western blot analysis of IL-37 in human lung tissue lysate with IL-37 antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.

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  Immunohistochemistry of IL-12A in human kidney tissue with IL-12A antibody at 5 ug/mL.

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  Immunofluorescence of IL-12A in human kidney tissue with IL-12A antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-37 antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.
• Formulation: IL-37 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IL-37 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 24 kDa; Observed: 23 kDa
• Gene Name: interleukin 37
• Database Link:
  NP_055254
  Entrez Gene 27178 Human
  UniProt ID Q9NZH6
• Background: Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1). It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). IL-37 also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1). IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2,3).
• Synonyms: FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H; IL-1H4; IL-1RP1; IL-37; IL1F7; IL1H4; IL1RP1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein