IL1RL2 Rabbit Polyclonal Antibody

CAT#: TA326663

Rabbit Polyclonal IL-1RL2 Antibody

Product Images

Western blot analysis of IL-1RL2 in human small intestine lysate with IL-1RL2 antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of IL-1RL2 in human small intestine tissue with IL-1RL2 antibody at 5 ug/mL.

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  Immunofluorescence of IL-1RL2 in human small intestine tissue with IL-1RL2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-1RL2 antibody was raised against a 16 amino acid peptide near the center of human IL-1RL2.
• Formulation: IL-1RL2 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IL-1RL2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 61 kDa; Observed: 55 kDa
• Gene Name: interleukin 1 receptor like 2
• Database Link:
  NP_003845
  Entrez Gene 107527 MouseEntrez Gene 171106 RatEntrez Gene 8808 Human
  UniProt ID Q9HB29
• Background: IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1). Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2). IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3).
• Synonyms: IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2

Reference Data

• Protein Families: Druggable Genome, Transmembrane