IL36 alpha (IL36A) Rabbit Polyclonal Antibody

CAT#: TA326665

Rabbit Polyclonal IL-36A Antibody

Product Images

Western blot analysis of IL-36A in MCF7 cell lysate with IL-36A antibody at 1 ?g/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of IL-36A in human brain tissue with IL-36A antibody at 5 ?g/mL.

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  Immunofluorescence of IL-36A in human brain tissue with IL-36A antibody at 20 ?g/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-36A antibody was raised against an 11 amino acid peptide near the carboxy terminus of human IL-36A.
• Formulation: IL-36A antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IL-36A antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 17 kDa; Observed: 16 kDa
• Gene Name: interleukin 36, alpha
• Database Link:
  NP_055255
  Entrez Gene 27179 Human
  UniProt ID Q9UHA7
• Background: IL-36A is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36A is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP (2). Like the related proteins IL-36B and IL-36G, IL-36A requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (3). The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells (4).
• Synonyms: FIL1; FIL1(EPSILON); FIL1E; IL-1F6; IL1(EPSILON); IL1F6

Reference Data

• Protein Families: Druggable Genome, Secreted Protein