IL36RN Rabbit Polyclonal Antibody

CAT#: TA326668

Rabbit Polyclonal IL-36RN Antibody

Product Images

Western blot analysis of IL-36RN in 3T3 cell lysate with IL-36RN antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of IL-36RN in rat small intestine tissue with IL-36RN antibody at 5 ug/mL.

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  Immunofluorescence of IL-36RN in rat small intestine tissue with IL-36RN antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-36RN antibody was raised against a 19 amino acid peptide near the carboxy terminus of human IL-36RN.
• Formulation: IL-36RN antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IL-36RN antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 17 kDa; Observed: 27 kDa
• Gene Name: interleukin 36 receptor antagonist
• Database Link:
  NP_775262
  Entrez Gene 26525 Human
  UniProt ID Q9UBH0
• Background: IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2). The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3). Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4).
• Synonyms: FIL1; FIL1(DELTA); FIL1D; IL-36Ra; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; PSORP; PSORS14

Reference Data

• Protein Families: Druggable Genome, Secreted Protein