BHLHA15 Rabbit Polyclonal Antibody

CAT#: TA326672

Rabbit Polyclonal BHLHA15 Antibody

Product Images

Western blot analysis of BHLHA15 in rat small Intestine tissue lysate with BHLHA15 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide

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  Immunohistochemistry of BHLHA15 in human small intestine tissue with BHLHA15 antibody at 5 ug/mL.

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  Immunofluorescence of BHLHA15 in human small intestine tissue with BHLHA15 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: BHLHA15 antibody was raised against a 18 amino acid peptide near the center of human BHLHA15.
• Formulation: BHLHA15 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: BHLHA15 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 21 kDa; Observed: 24 kDa
• Gene Name: basic helix-loop-helix family member a15
• Database Link:
  NP_803238
  Entrez Gene 17341 MouseEntrez Gene 25334 RatEntrez Gene 168620 Human
  UniProt ID Q7RTS1
• Background: BHLHA15 (basic helix-loop-helix protein 15), also known as MIST1 (muscle intestine and stomach expression 1) belongs to the bHLH family of transcription factors and plays a role in regulating the transcriptional activity of MYOD1 in muscle cell development as well as serving as a key regulator of acinar cell function (1,2). BHLHA15 contains a basic helix-loop-helix (bHLH) domain and is capable of binding to E-box motifs as a homodimer or a heterodimer with E-proteins. It may also negatively regulate bHLH-mediated transcription through a N-terminal repressor domain (3). It is expressed in mammary epithelial cells and is essential for the regulation of mammary gland development (4).
• Synonyms: BHLHB8; MIST1

Reference Data

• Protein Pathways: Maturity onset diabetes of the young