SDF1 (CXCL12) Rabbit Polyclonal Antibody

CAT#: TA326687

Rabbit Polyclonal CXCL12 Antibody

Product Images

Western blot analysis of CXCL12 in HeLa cell lysate with CXCL12 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunocytochemistry of CXCL12 in HeLa cells with CXCL12 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CXCL12 antibody was raised against a 16 amino acid peptide near the center of human CXCL12
• Formulation: CXCL12 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: CXCL12 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 15 kDa; Observed: 18 kDa
• Gene Name: C-X-C motif chemokine ligand 12
• Database Link:
  NP_954637
  Entrez Gene 20315 MouseEntrez Gene 6387 Human
  UniProt ID P48061
• Background: The CXCL12 protein, also known as SDF1, is a stromal cell-derived alpha chemokine member of the intercrine family. CXCL12 functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4 (CXCR4) and CXCR7, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis (reviewed in 1). Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections (2).
• Synonyms: IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
• Protein Pathways: Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Leukocyte transendothelial migration