DRP1 (DNM1L) Rabbit Polyclonal Antibody

CAT#: TA326690

Rabbit Polyclonal DNM1L Antibody

Product Images

Western blot analysis of DNM1L in HeLa cell lysate with DNM1L antibody at 1 ug/ml.

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  Immunocytochemistry of DNM1L in HeLa cells with DNM1L antibody at 5 ug/mL.

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  Immunofluorescence of DNM1L in HeLa cells with DNM1L antibody at 20 ug/mL.

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  Immunocytochemistry of DNM1L in HeLa cells with DNM1L antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNM1L antibody was raised against a 19 amino acid peptide near the center of human DNM1L.
• Formulation: DNM1L antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DNM1L antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 81 kDa; Observed: 80 kDa
• Gene Name: dynamin 1-like
• Database Link:
  NP_036192
  Entrez Gene 74006 MouseEntrez Gene 10059 Human
  UniProt ID O00429
• Background: The Dynamin-1-like protein (DNM1L) is a member of the dynamin superfamily of GTPases (1). DNM1L mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis (2). Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) (3).
• Synonyms: DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV

Reference Data

• Protein Pathways: Endocytosis, Fc gamma R-mediated phagocytosis